Project information
CIISB - Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2023042
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Project Website
- https://www.ciisb.org/
- Cooperating Organization
-
Institute of Biotechnology CAS
- Responsible person Ing. Jan Dohnálek, PhD.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed national infrastructure, which consists of two nodes, one represented by CEITEC (Central European Institute of Technology, Brno) and second by BIOCEV (Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Vestec near Prague). CIISB offers access to 10 core facilities; five of them are part of the Centre of Structural Biology and one of the Mendel Centre of Genomics and Proteomics of Plants of CEITEC Masaryk University and four of the Centre of Molecular Structure of the Institute of Biotechnology AS CR in the BIOCEV Centre.
All CIISB core facilities are in the full operational phase. Projects as OP RDI (Start-up) supported the construction phase, and the built capacities were made available by both CIISB nodes in the form of Open Access to internal and external users. In its construction phase, CIISB (2011-2015) was the Associated National Center of the pan-European research infrastructure INSTRUCT. In 2016, following the completion, putting into operation, and subsequent international evaluation, CIISB became a fully-fledged Instruct-CZ Centre for this distributed infrastructure.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 131
2025
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Structural basis of bis-quinolinium ligands binding to quadruplex-duplex hybrids from PIM1 oncogene
Nucleic Acids Research, year: 2025, volume: 53, edition: 17, DOI
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Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals
Chemical Science, year: 2025, volume: 16, edition: 43, DOI
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Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights
ACS Infectious Diseases, year: 2025, DOI
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Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth
Cell Communication and Signaling, year: 2025, volume: 23, edition: 1, DOI
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The insight into the biology of five homologous lectins produced by the entomopathogenic bacterium and nematode symbiont Photorhabdus laumondii
Glycobiology, year: 2025, volume: 35, edition: 7, DOI
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The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies by 13C-Direct Detected NMR Spectroscopy
Analytical chemistry, year: 2025, volume: 97, edition: 7, DOI
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TP53 detection based on electrochemical genosensors with different types of gold nanoparticles
Microchemical Journal, year: 2025, volume: 209, edition: February 2025, DOI
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Two new psychrotolerant Massilia species inhibit plant pathogens Clavibacter and Curtobacterium
Scientific Reports, year: 2025, volume: 15, edition: 1, DOI
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Tyrosine-specific bioconjugation allowing hole hopping along aromatic chains of glucose oxidase
Materials Horizons, year: 2025, volume: 12, edition: 16, DOI
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Unravelling the mysteries of novel two-domain lectins from opportunistic human pathogens
Year: 2025, type: Conference abstract