Project information
CIISB - Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2023042
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Project Website
- https://www.ciisb.org/
- Cooperating Organization
-
Institute of Biotechnology CAS
- Responsible person Ing. Jan Dohnálek, PhD.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed national infrastructure, which consists of two nodes, one represented by CEITEC (Central European Institute of Technology, Brno) and second by BIOCEV (Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Vestec near Prague). CIISB offers access to 10 core facilities; five of them are part of the Centre of Structural Biology and one of the Mendel Centre of Genomics and Proteomics of Plants of CEITEC Masaryk University and four of the Centre of Molecular Structure of the Institute of Biotechnology AS CR in the BIOCEV Centre.
All CIISB core facilities are in the full operational phase. Projects as OP RDI (Start-up) supported the construction phase, and the built capacities were made available by both CIISB nodes in the form of Open Access to internal and external users. In its construction phase, CIISB (2011-2015) was the Associated National Center of the pan-European research infrastructure INSTRUCT. In 2016, following the completion, putting into operation, and subsequent international evaluation, CIISB became a fully-fledged Instruct-CZ Centre for this distributed infrastructure.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 152
2026
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Proteomics-Based Study of Potential Emphysema Biomarkers Reveals Systemic Redox System and Extracellular Matrix Component Dysregulation
Diagnostics, year: 2026, volume: 16, edition: 6, DOI
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Psychrotolerant Erwinia psychrophila sp. nov. and Erwinia magellanica sp. nov. Isolated from Penguin Faeces
CURRENT MICROBIOLOGY, year: 2026, volume: 83, edition: 2, DOI
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SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of meiotic bodies
Nature Communications, year: 2026, volume: 17, edition: 1, DOI
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Structural basis of βKNL2 centromeric targeting mechanism and its role in plant-specific kinetochore assembly
NUCLEIC ACIDS RESEARCH, year: 2026, volume: 54, edition: 12, DOI
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Structural insights into the evolution of alpha/beta-hydrolase fold luciferases
International journal of biological macromolecules, year: 2026, volume: 361, edition: May 2026, DOI
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Translational control of AMPK activity in melanoma
Cell Communication and Signaling, year: 2026, volume: 24, edition: 1, DOI
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Triazinyl-benzenesulfonamide derivatives as hCA IX inhibitors: Design, synthesis, and activity determination using an optimized stop-flow methodology
BIOORGANIC CHEMISTRY, year: 2026, volume: 170, edition: March, DOI
2025
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: From Single Molecules to Tissues: Correlative BioAFM Serving as Core Facility
Year: 2025, type: Conference abstract
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3rd ML4NGP Training School "NMR for Intrinsically Disordered Proteins (IDPs)"
Year: 2025, type: Holding a workshop
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AFM application across the life sciences field and its combination with special techniques
Year: 2025, type: Conference abstract