Project information
CIISB - Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2023042
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Project Website
- https://www.ciisb.org/
- Cooperating Organization
-
Institute of Biotechnology CAS
- Responsible person Ing. Jan Dohnálek, PhD.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed national infrastructure, which consists of two nodes, one represented by CEITEC (Central European Institute of Technology, Brno) and second by BIOCEV (Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Vestec near Prague). CIISB offers access to 10 core facilities; five of them are part of the Centre of Structural Biology and one of the Mendel Centre of Genomics and Proteomics of Plants of CEITEC Masaryk University and four of the Centre of Molecular Structure of the Institute of Biotechnology AS CR in the BIOCEV Centre.
All CIISB core facilities are in the full operational phase. Projects as OP RDI (Start-up) supported the construction phase, and the built capacities were made available by both CIISB nodes in the form of Open Access to internal and external users. In its construction phase, CIISB (2011-2015) was the Associated National Center of the pan-European research infrastructure INSTRUCT. In 2016, following the completion, putting into operation, and subsequent international evaluation, CIISB became a fully-fledged Instruct-CZ Centre for this distributed infrastructure.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 131
2025
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Evidence of in vitro mecB-mediated β-lactam antibiotic resistance transfer to Staphylococcus aureus from Macrococcus psychrotolerans sp. nov., a psychrophilic bacterium from food-producing animals and human clinical specimens
Applied and Environmental Microbiology, year: 2025, volume: 91, edition: 4, DOI
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Exploring Mechanical Properties of Soft Materials at the Nanoscale Using Indentation Methods
Year: 2025, type: Conference abstract
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Flexibility-Aided Orientational Self-Sorting and Transformations of Bioactive Homochiral Cuboctahedron Pd12L16
Angewandte Chemie International Edition, year: 2025, volume: 64, edition: 37, DOI
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Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins
International Journal of Biological Macromolecules, year: 2025, volume: 305, edition: MAY, DOI
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How does phosphorylation of 14-3-3ζ protein affect its structure and function?
Year: 2025, type: Conference abstract
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Characterisation of Alzheimer's-disease-relevant Tau protein expressed in HEK293 mammalian cells
Year: 2025, type: Conference abstract
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Characterization of Heterorhabditis bacteriophora response to insect-derived and non-biological stimuli: Insights into nematode recovery and released proteins
Pesticide Biochemistry and Physiology, year: 2025, volume: 208, edition: March, DOI
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In search of the unknown functions of honey bee apolipophorin-1
Year: 2025, type: Appeared in Conference without Proceedings
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Interaction process behind the strong stabilization of G-quadruplexes by alkaloid fagaronine
Biophysical Chemistry, year: 2025, volume: 323, edition: August 2025, DOI
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Isolation of a Unique Monoterpene Diperoxy Dimer From Ziziphora clinopodioides subsp. bungeana Together With Triterpenes With Antidiabetic Properties
Phytochemical Analysis, year: 2025, volume: 36, edition: 4, DOI