Project information
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
- Project Identification
- NU22-02-00348
- Project Period
- 5/2022 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Tomáš Novotný, Ph.D.
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 34
2023
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Possible proarrhythmic stimuli in Y4734C-RYR2 variant associated with idiopathic ventricular fibrillation
Year: 2023, type: Conference abstract
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Spontaneous electrical activity of cardiomyocytes derived from hiPSCs of a patient with idiopathic ventricular fibrillation and RYR2 variant: impact of isoprenaline and varying concentrations of Ca2+
Year: 2023, type: Conference abstract
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Změny spontánní aktivity derivovaných kardiomyocytů s variantou Y4734C-RYR2 za vybraných arytmogenních podmínek
Year: 2023, type: Conference abstract
2022
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A new approach to the determination of tubular membrane capacitance: passive membrane electrical properties under reduced electrical conductivity of the extracellular solution
Pflügers Archiv - European Journal of Physiology, year: 2022, volume: 474, edition: 12, DOI
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Action potential characteristics in derived cardiomyocytes of a patient carrying RYR2 variant
Year: 2022, type: Conference abstract
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Assessment of the fraction of t-tubular membrane in cardiomyocytes: a new and reversible approach
Year: 2022, type: Conference abstract
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Fraction of the T-Tubular Membrane as an Important Parameter in Cardiac Cellular Electrophysiology: A New Way of Estimation
Frontiers in Physiology, year: 2022, volume: 13, edition: May 2022, DOI
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Genetické varianty asociované s idiopatickou fibrilací komor: role dysfunkce RYR2 kanálu
Year: 2022, type: Conference abstract
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Idiopathic ventricular fibrillation as an inherited channelopathy?
Year: 2022, type: Conference abstract
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Inherited arrhythmias: from gene variants to ionic channel dysfunctions
Year: 2022, type: