Project information
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
- Project Identification
- NU22-02-00348
- Project Period
- 5/2022 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Tomáš Novotný, Ph.D.
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 34
2024
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Analysis of calcium transients in cardiomyocytes derived from hiPSCs: the variant p. Y4734C in RYR2 vs. unrelated healthy controls
Year: 2024, type: Conference abstract
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Analýza variability délky cyklu u pacient-specifických hiPSC kardiomyocytů
Year: 2024, type: Conference abstract
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Dopad varianty S1021Qfs*98-hERG na funkci proteinu Kv11.1
Year: 2024, type: Conference abstract
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Effect of isoprenaline and arrhythmogenic conditions on the spontaneous electrical activity of hiPSC-CM with Y4734C-RYR2 variant
Year: 2024, type: Conference abstract
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Functional consequences of changes in the distribution of Ca2+ extrusion pathways between t-tubular and surface membranes in a model of human ventricular cardiomyocyte
Journal of Molecular and Cellular Cardiology, year: 2024, volume: 193, edition: August 2024, DOI
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Generation of human induced pluripotent stem cell lines from patients with a RYR2 gene variant c.14201A>G (p.Y4734C): Implications for idiopathic ventricular fibrillation and catecholaminergic polymorphic ventricular tachycardia
Stem cell research, year: 2024, volume: 81, edition: December 2024, DOI
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Idiopathic Ventricular Fibrillation - Just How Much Idiopathic is it?
Reviews in Cardiovascular Medicine, year: 2024, volume: 25, edition: 8, DOI
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Idiopathic ventricular fibrillation: a role of variants in the hERG gene
Year: 2024, type: Conference abstract
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Idiopatická fibrilace komor a její možný genetický podklad
Year: 2024, type: Conference abstract
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Pacient-specifické kardiomyocyty s variantou Y4734C-RYR2: Ca2+ přechody v kontrole a po aplikaci kofeinu
Year: 2024, type: Conference abstract