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Project information
Mechanorecepce jako mechanizmus řídící odontogenezi napříč obratlovci

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.
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Project Identification
GA22-02794S
Project Period
1/2022 - 12/2024
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
Institute of Animal Physiology and Genetics of thr ASCR, v. v. i.
  • Responsible person doc. RNDr. Marcela Buchtová, Ph.D.

Tooth development is precisely controlled system with the involvement of different pools of stem cell niches. However, the cellular mechanisms underlaying tooth growth and dental tissue repair still remain to be elusive. The main aim of this project is to determine the role of cellular mechanosensing and associated signalling in regulation of tooth growth and the contribution of these processes in the healing of dental tissues. Rodent incisors and their tooth-bone interphase area will be used as a model to study permanent grow activity and mouse molars will serves as a model of soft tissue damage leading to ankylosis. Moreover, comparison with other vertebrate species will help us to uncover if mechanosensing is a general mechanism used by all vertebrates regardless on morphology of tooth-bone area during odontogenesis. This project will help us also to understand mechanisms involved in reparative and regenerative odontogenesis and to tack more general questions extending beyond the dental field, which will provide new insight to the regulation of developmental and healing processes.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 6

2024

2023

2022

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