Informace o projektu
Mechanorecepce jako mechanizmus řídící odontogenezi napříč obratlovci
- Kód projektu
- GA22-02794S
- Období řešení
- 1/2022 - 12/2024
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
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Lékařská fakulta
- doc. Mgr. Jan Křivánek, Ph.D.
- Klára Cigošová
- Marcos González López, MSc.
- Bc. Margarita Gorbulina
- Ema Grofová
- doc. Ing. Petr Henyš, Ph.D.
- Adéla Kadlecová
- Magdaléna Koloušková
- Mgr. Josef Lavický
- Spolupracující organizace
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Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
- Odpovědná osoba doc. RNDr. Marcela Buchtová, Ph.D.
Tooth development is precisely controlled system with the involvement of different pools of stem cell niches. However, the cellular mechanisms underlaying tooth growth and dental tissue repair still remain to be elusive. The main aim of this project is to determine the role of cellular mechanosensing and associated signalling in regulation of tooth growth and the contribution of these processes in the healing of dental tissues. Rodent incisors and their tooth-bone interphase area will be used as a model to study permanent grow activity and mouse molars will serves as a model of soft tissue damage leading to ankylosis. Moreover, comparison with other vertebrate species will help us to uncover if mechanosensing is a general mechanism used by all vertebrates regardless on morphology of tooth-bone area during odontogenesis. This project will help us also to understand mechanisms involved in reparative and regenerative odontogenesis and to tack more general questions extending beyond the dental field, which will provide new insight to the regulation of developmental and healing processes.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 6
2024
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Unveiling vertebrate development dynamics in frog Xenopus laevis using micro-CT imaging
GigaScience, rok: 2024, ročník: 13, vydání: JUNE, DOI
2023
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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
Nature Communications, rok: 2023, ročník: 14, vydání: 1, DOI
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Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue
Scientific Reports, rok: 2023, ročník: 13, vydání: 1, DOI
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Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development
Science Advances, rok: 2023, ročník: 9, vydání: 31, DOI
2022
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Mouse molar development and the role of mechanosensation in the root formation
Rok: 2022, druh: Konferenční abstrakty
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Revealing the complexity of mesenchymal stem cell niche of continuously growing teeth
Rok: 2022, druh: Konferenční abstrakty