Project information
National Center for Medical Genomics
(NCLG)
- Project Identification
- LM2018132
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Charles University
- Responsible person prof. Ing. Stanislav Kmoch, CSc.
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 78
2021
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Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model
Journal of Clinical Medicine, year: 2021, volume: 10, edition: 11, DOI
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Distribution of SARS-CoV-2 Lineages in the Czech Republic, Analysis of Data from the First Year of the Pandemic
Microorganisms, year: 2021, volume: 9, edition: 8, DOI
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Evolution of plant telomerase RNAs: farther to the past, deeper to the roots
Nucleic acids research, year: 2021, volume: 49, edition: 13, DOI
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FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia
Blood, year: 2021, volume: 138, edition: 9, DOI
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Functional analysis of new variant GP1BA gene in inherited macrotrombocytopenia.
Year: 2021, type: Conference abstract
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Histopathology of laboratory-reared Nothobranchius fishes: Mycobacterial infections versus neoplastic lesions
Journal of Fish Diseases, year: 2021, volume: 44, edition: 8, DOI
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miR-29 influences CD40 signaling in chronic lymphocytic leukemia (CLL): and axis affected by BCR inhibitors.
Year: 2021, type: Conference abstract
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miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors
Blood, year: 2021, volume: 137, edition: 18, DOI
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Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis
Frontiers in Immunology, year: 2021, volume: 12, edition: December 2021, DOI
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Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma-piR-9491 and piR-12488 Reduce Tumor Cell Colonies In Vitro
Frontiers in Oncology, year: 2021, volume: 11, edition: AUG, DOI