Project information
National Center for Medical Genomics
(NCLG)
- Project Identification
- LM2018132
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Charles University
- Responsible person prof. Ing. Stanislav Kmoch, CSc.
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 78
2022
-
Multidisciplinary approach to identification of Gregor Johann Mendel's skeletal remains
Folia Mendeliana : supplementum ad Acta Musei Moraviae, year: 2022, volume: 58, edition: 1
-
Reconstructing of the genome of Gregor Johann Mendel using state-of-the-art molecular and bioinformatics tools
Year: 2022, type: Conference abstract
-
Single and multiple point NRAS mutations in acute myeloid leukemia: a study of 327 well molecularly characterized patients.
LEUKEMIA & LYMPHOMA, year: 2022, volume: 63, edition: 13, DOI
-
Single-cell RNA sequencing analysis of T helper cell differentiation and heterogeneity
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, year: 2022, volume: 1869, edition: 10, DOI
-
Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds
Journal of Virology, year: 2022, volume: 96, edition: 17, DOI
-
The mechanical regulation of RNA binding protein hnRNPC in the failing heart
Science Translational Medicine, year: 2022, volume: 14, edition: 672, DOI
-
Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host's body temperature
SCIENTIFIC REPORTS, year: 2022, volume: 12, edition: 1, DOI
-
Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient
CLINICAL CASE REPORTS, year: 2022, volume: 10, edition: 3, DOI
2021
-
Business Research Forum
Year: 2021, type: Popularization text
-
CF Day
Year: 2021, type: Conference