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Project information
Early diagnostics of leukemia using DNA-microchip technology and by monitoring of epigenetic changes

Information

This project doesn't include Faculty of Science. It includes Faculty of Informatics. Official project website can be found on muni.cz.
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Project Identification
GP301/04/P136
Project Period
1/2004 - 12/2006
Investor / Pogramme / Project type
Czech Science Foundation
  • Postdoctoral projects
MU Faculty or unit
Faculty of Informatics
Keywords
DNA-microchipes, leukemia, epigenetic changes, chromatin structure

Using DNA-microchip technology expression maps in cells of bone marrow or immobilized blood of patients with different types of leukaemia at different stages will be obtained and compared with results obtained from cells without effect of cancer. The differences found by comparing expression maps of cells with various level of progression and differentiation will help us to the identify primary, yet known, but also new genes whose false function contributes to the disease development.
Also it should be clarified how the changes of activity of these genes reflect the activity of other known or unknown genes and what is the location of these genes on corresponding chromosomes. For epigenetic changes FISH and high-resolution cytometry will be used. Chromosomes with modulated level of expression will be interrogated structural-epigenetic-study. Changes in structure of chromatin in the cells of patients with leukaemia in the various stages of diseases in contrast to non-cancer cells will be evaluated

Results

Publications

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