Loschmidt Laboratories of Protein Engineering

Articles

• Accessible biocatalyst development by rapid in vitro semi-rational engineering (RISE) of enzymes

  TELEK Andras GAJAK Viktor Zsolt DARGO Gergo MIČAN Jan BEDNÁŘ David VERTESSY Beata G. TASNADI Gabor

  Peer-reviewed scientific article

  iScience, year: 2026, volume: 29, edition: 1, DOI

• Aicardi-Goutieres Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant-Negative Effect of the ADAR1 c.3019G>A Variant

  TURAN Kateřina POKORNÁ Petra ŘÍHOVÁ Kamila KUBÁTOVÁ Jana KOŽELKOVÁ Kateřina HLOUŠKOVÁ Eliška DANHOFER Pavlína JABANDŽIEV Petr DAMBORSKÝ Jiří DEMLOVÁ Regina SLABÝ Ondřej SLABÁ Kateřina

  Peer-reviewed scientific article

  CLINICAL CASE REPORTS, year: 2026, volume: 14, edition: 4, DOI

• Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease

  STOJASPAL Martin BROM Tomáš NEČASOVÁ Ivona JANOVIČ Tomáš VEVERKA Pavel VERMA Naina UHRÍK Lukáš HERNYCHOVÁ Lenka HOFR Ctirad

  Peer-reviewed scientific article

  FEBS Journal, year: 2026, volume: 293, edition: 14, DOI

• Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy

  MODI Ajay MARIA Sheetal RUDÁ Jana DRAŽANOVÁ Eva HARAŠTOVÁ Iveta ŠEJNOHA MINSTEROVÁ Alžběta KOVAČOVICOVÁ Kristína HAVAS Daniel REKTOROVÁ Irena OUTEIRO Tiago F. KHAIRNAR Amit Suresh

  Peer-reviewed scientific article

  CNS Neuroscience & Therapeutics, year: 2026, volume: 32, edition: 4, DOI

• Concentration-dependent dimerization of staphylokinase variants with engineered surface charges

  NEMERGUT Michal STULAJTEROVA Monika SKRABANA Rostislav HOVAN Andrej AMBRO L'ubos STRUNGA Alan PROKOP Zbyněk DAMBORSKÝ Jiří TOMKOVA Maria SEDLAK Erik

  Peer-reviewed scientific article

  Protein Science, year: 2026, volume: 35, edition: 3, DOI

• Early-onset hereditary spastic paraplegia type 56 (SPG56): clinical-molecular correlations and functional validation of CYP2U1 variants

  ŠUSTROVÁ Eva ŘÍHOVÁ Kamila POKORNÁ Petra HAVLOVA Veronika STIBOREK Marek ŠIMEK Zdeněk DAMBORSKÝ Jiří HORÁK Ondřej KOŽELKOVÁ Kateřina HLOUŠKOVÁ Eliška DEMLOVÁ Regina KUBÁTOVÁ Jana SLABÝ Ondřej SLABÁ Kateřina

  Peer-reviewed scientific article

  BMC Medical Genomics, year: 2026, volume: 19, edition: 1, DOI

• FireProtDB 2.0: large-scale manually curated database of the protein stability data

  MUSIL Miloš BORKO Simeon PLANAS IGLESIAS Joan LACKO Dávid ROSINSKA Monika KABOUREK Petr MARTINS Ligia O. TATARUCH Mateusz DAMBORSKÝ Jiří MAZURENKO Stanislav BEDNÁŘ David

  Peer-reviewed scientific article

  NUCLEIC ACIDS RESEARCH, year: 2026, volume: 54, edition: D1, DOI

• Harmane inhibits hepatic cytochrome P450 enzymes in rats

  KLÁSKOVÁ Eva ZENDULKA Ondřej PEŠ Ondřej EYRILMEZ Saltuk Mustafa BEDNÁŘ David JUŘICA Jan

  Peer-reviewed scientific article

  Frontiers in Pharmacology, year: 2026, volume: 17, edition: August 2026, DOI

• Rapid screening of staphylokinase protein variants using an unpurified cell-free expression system

  TOMKOVA Maria HOVANOVA Veronika DAMBORSKÝ Jiří SEDLAK Erik

  Peer-reviewed scientific article

  FEBS Open Bio, year: 2026, DOI

• Regioselective Sesquiterpene Hydroxylation Directed by Tunnel Remodeling in Rieske Oxygenases

  BERGER Jonathan B. MARQUES Sérgio Manuel WISSNER Julian L. SCHELLE Jona T. BEEKWILDER Jules DAMBORSKÝ Jiří HAUER Bernhard

  Peer-reviewed scientific article

  JACS Au, year: 2026, volume: 6, edition: 2, DOI