Project information
řešitelka dr. Petra Vojáčková (Mgr. Petra Vojáčková, PhD)

The fundamental building blocks of all known life exhibit chirality. Therefore, the ability to synthesize chemical compounds as single mirror-image forms (enantiomers) is essential, particularly for applications in biological systems. However, achieving precise control over the stereoselectivity of highly reactive radical intermediates with chiral small-molecule catalysts remains a considerable challenge. Most catalytic strategies in stereoselective radical chemistry are limited to substrates containing specific functional groups for catalyst binding and induce selectivity through steric repulsion. New approaches for inducing enantioselectivity in radical reactions are needed to realize the full potential of radical chemistry in organic synthesis. This project will identify new approaches in selective catalysis by leveraging stabilizing interactions with open-shell intermediates and radical transition states. The goal of the proposed four-year project is to develop catalytic systems for enantioselective abstraction of hydrogen atoms by halogen radicals by harnessing noncovalent interactions.