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Project information
Molecular genetic aspects of proarrhythmic of non-antiarrhythmic drugs

Project Identification
NA7424
Project Period
1/2003 - 12/2005
Investor / Pogramme / Project type
Ministry of Health of the CR
  • R&D of Cardiovascular Diseases
MU Faculty or unit
Faculty of Science
Keywords
proarrhyhtmia; QT interval; torsade de pointes; gene; mutation; long QT syndrome
Cooperating Organization
University Hospital Brno-Bohunice
  • Responsible person prof. MUDr. Tomáš Novotný, Ph.D.

QT interval prolongation and increased risk of sudden death are adverse effects of long list of widely used drugs. The fenomenon has been called the acquired long QT syndrome and its mechanism remains unclear. The congenital long QT syndrome is underlain by cardiac ion channel genes. Mutational analysis of these genes in cases of proarrhythmia will contribute to understanding of arrhythmogenesis.

Results

The project assessed the occurence of proarrhythmia (by QT interval monitoring) and its molecular-genetic aspects. The occurence of drug-induced QT prolongation was lower than in literature. In 1 patient with prolonged QT a KCNQ1 gene mutation was found.

Publications

Total number of publications: 3

2007

2005

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