Project information
Národní infrastruktura chemické biologie
- Project Identification
- LM2023052
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Faculty of Science
- doc. Mgr. Kamil Paruch, Ph.D.
- RNDr. Petr Beňovský, Ph.D.
- Michael Christopher Böck, Ph.D.
- Raju Hazra
- Abhijeet Jadhav
- PrashantKumar Khirsariya, Ph.D., M.Sc.
- Mgr. Lukáš Maier, Ph.D.
- Paula Martín Moyano
- Taufiqueahmed Pirsaheb Mujawar
- RNDr. Marek Remeš, Ph.D.
- Mgr. Petr Sevelda
- Viacheslav Igorevich Shkepu
- Mgr. Adam Štefek
- Mgr. Jiří Švejkar
- Mgr. Jakub Švenda, PhD.
- Cooperating Organization
-
Institute of Molecular Genetics of the ASCR, v. v. i.
- Responsible person RNDr. Petr Bartůněk, CSc.
- Responsible person MUDr. Petr Džubák, Ph.D.
- Responsible person prof. Mgr. Daniel Svozil, Ph.D.
The aim of the project „CZ-‐OPENSCREEN: National infrastructure for chemical biology” is to operate the state-‐of-‐the-‐art infrastructure for basic and applied research in the fields of chemical biology and genetics and provide Open Access to users. It will serve as the National node of the pan-European ESFRI infrastructure EU-‐OPENSCREEN, providing trans-‐national access to the Screening platform and to the European Chemical Biology Library. The mission of CZ-‐OPENSREEN is to identify new molecular probes/tools for research and new potential therapeutics.
Publications
Total number of publications: 9
2024
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A Platform for the Synthesis of Oxidation Products of Bilirubin
Journal of the American Chemical Society, year: 2024, volume: 146, edition: 2, DOI
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Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2
Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI
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Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells
Biological Chemistry, year: 2024, volume: 405, edition: 6, DOI
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Merging Bambus[6]uril and Biotin[6]uril into an Enantiomerically Pure Monofunctionalized Hybrid Macrocycle
Organic Letters, year: 2024, volume: 26, edition: 1, DOI
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Multimodal Carbon Monoxide Photorelease from Flavonoids
Organic Letters, year: 2024, volume: 26, edition: 3, DOI
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Thermal Truncation of Heptamethine Cyanine Dyes
Journal of the American Chemical Society, year: 2024, volume: 146, edition: 29, DOI
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Tuning CH Hydrogen Bond-Based Receptors toward Picomolar Anion Affinity via the Inductive Effect of Distant Substituents
Angewandte Chemie, year: 2024, volume: 136, edition: 5, DOI
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Unexpectedly Regioselective Diels-Alder Reactions of New Unsymmetrical Benzoquinones: A Convenient Synthetic Entry to Uniquely Substituted Decalins
Chemistry - A European Journal, year: 2024, volume: 30, edition: 55, DOI
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Visible-Light-Activated Carbon Monoxide Release from Porphyrin-Flavonol Hybrids
Journal of the American Chemical Society, year: 2024, volume: 146, edition: 1, DOI