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Project information
Identification and role of proteins in control and degradation of RNA and regulation of gene expression

Information

This project doesn't include Faculty of Science. It includes Central European Institute of Technology. Official project website can be found on muni.cz.
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Project Identification
GA23-07372S
Project Period
1/2023 - 12/2025
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Central European Institute of Technology

The function of eukaryotic cell sis regulated at many levels. One of the key mechanisms is the regulation of gene/protein expression. Gene expression can be affected several steps by directly modifying RNA synthesis or by changing RNA processing, modifications or stability. 3‘ terminal modifications can regulate mRNA biology and protein synthesis by direct mRNA modification or via regulation of noncoding RNAs. In this project we will investigate how 3‘ terminal tailing affects synthesis of small regulatory molecules and how this impacts cellular physiology. We aim to uncover new factors that play a role in the regulation of 3’ tailing and stability of ncRNAs and tackle their role in the regulation of gene expression. We will study at least three different cells to search for possible regulatory differences.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 4 – Quality education Sustainable Development Goal No. 5 – Gender equality Sustainable Development Goal No. 9 – Industry, innovation and infrastructure Sustainable Development Goal No. 15 – Life on land

Publications

Total number of publications: 2

2023

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