Project information
Characterization of the RAD51 role in TERRA recruitment to telomere
- Project Identification
- MUNI/IGA/1223/2021
- Project Period
- 1/2022 - 12/2022
- Investor / Pogramme / Project type
-
Masaryk University
- Internal grant agency MU
- MU Faculty or unit
- Faculty of Medicine
Telomeric repeat containing RNA (TERRA) was revealed to be recruited to telomeres by RAD51 protein by the mechanism resembling strand-invasion and homology-search mechanism utilized in homology directed DNA repair (HDR). However, detailed mechanism of TERRA recruitment remains uncovered. We would like to focus on biochemical characterization of RAD51-TERRA interaction and regulation of TERRA recruitment.