Project information
Dynamics of telomeres and rDNA loci in plant cell nuclei
- Project Identification
- LTC20003
- Project Period
- 6/2020 - 4/2023
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- INTER-EXCELLENCE
- INTER-COST
- MU Faculty or unit
- Central European Institute of Technology
The cell nucleus and its detailed structure has always represented an exciting cellular compartment and stimulated establishment of the new research areas and innovative methodologies. Plants represent important model systems with a high developmental plasticity and variable organization of their genomes, differing, e.g., in the genome size, proportion of repetitive elements or the chromosome numbers. Our research group integrates studies in the field of telomere biology, chromatin structure, DNA repair and epigenetics. Rapid progress of the cell biology occurred in line with development of super-resolution microscopy approaches and advanced assays to investigate chromatin organization, allowing a detailed insight into the spatial organization of individual nuclear subdomains and other functional elements, such as nucleolus, telomeres or clusters of ribosomal rRNA genes. In the proposed project, we will investigate the effect of molecular and environmental factors on telomere composition and telomerase regulation and decipher functional links between chromatin assembly and epigenetic memory in the telomere maintenance, representing a good measure of overall genome stability.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 12
2023
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Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Cell Reports, year: 2023, volume: 42, edition: 8, DOI
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Identification of the Sequence and the Length of Telomere DNA
Plant Cytogenetics and Cytogenomics : Plant Cytogenetics and Cytogenomics, year: 2023, number of pages: 18 s.
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Sulfate supplementation affects nutrient and photosynthetic status of Arabidopsis thaliana and Nicotiana tabacum differently under prolonged exposure to cadmium
Journal of Hazardous Materials, year: 2023, volume: 445, edition: March, DOI
2022
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Laser microirradiation as a versatile system for probing protein recruitment and protein-protein interactions at DNA lesions in plants
New Phytologist, year: 2022, volume: 234, edition: 5, DOI
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MEDIATOR SUBUNIT17 integrates jasmonate and auxin signaling pathways to regulate thermomorphogenesis
Plant Physiology, year: 2022, volume: 189, edition: 4, DOI
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Telomerase Interaction Partners-Insight from Plants
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 1, DOI
2021
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Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 1, DOI
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G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability
Plant Physiology, year: 2021, volume: 186, edition: 4, DOI
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Super-resolution microscopy of chromatin fibers and quantitative DNA methylation analysis of DNA fiber preparations
Journal of Cell Science, year: 2021, volume: 134, edition: 15, DOI
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The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants
Journal of Experimental Botany, year: 2021, volume: 72, edition: 2, DOI