Project information
Vliv pneumologické medikace na funkce lidských kardiomyocytů
- Project Identification
- NU20-06-00156
- Project Period
- 5/2020 - 12/2023
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Kristián Brat, Ph.D.
Projekt se bude zabývat mechanizmem vzniku kardiomyopatie působením kombinací bronchodilatačních léčiv, za použití kardiomyocytů odvozených z pluripotentních kmenových buněk, získaných reprogramací primárních kultur z biopsií pacienů.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 26
2025
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3D elektromechanické biosenzory buněk pro screenig léčiv a onemocnění
Year: 2025, type: Appeared in Conference without Proceedings
2024
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A narrative review of theophylline: is there still a place for an old friend?
Journal of Thoracic Disease, year: 2024, volume: 16, edition: 5, DOI
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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner
Biomedicine & Pharmacotherapy, year: 2024, volume: 181, edition: December 2024, DOI
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Microphysiological Analysis of Cardiomyocyte Function in 3D Organoids
Year: 2024, type: Conference abstract
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Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model
Scientific Reports, year: 2024, volume: 14, edition: 1, DOI
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SALBUTAMOL TLUMÍ ARYTMOGENNÍ ÚČINEK AMINOFYLINU V KARDIÁLNÍM MODELU Z INDUKOVANÝCH PLURIPOTENTNÍCH KMENOVÝCH BUNĚK
Year: 2024, type: Conference abstract
2023
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3D elektromechanické buněčné biosenzory pro screenig léčiv a onemocnění
Year: 2023, type: Appeared in Conference without Proceedings
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Cardiovascular Diseases
Mechanics in Diseased Cells and Tissues, Volume 2 Biomedical Applications, year: 2023, number of pages: 26 s.
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DUAL CARDIOMYOCYTE CLUSTER DETECTION OF THE DIFFERENT TYPES OF ARRHYTHMOGENIC POTENTIAL OF DRUGS
Year: 2023, type: Conference abstract
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Effects of salbutamol and its combination with aminophylline on human stem cell-derived cardiomyocytes′ function.
Year: 2023, type: Conference abstract