Project information
Národní centrum lékařské genomiky
(NCLG)
- Project Identification
- LM2015091
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Charles University
- Responsible person doc. Ing. Stanislav Kmoch, CSc.
University Hospital Pilsen
University Hospital Prague - Motol
University Hospital Brno-Bohunice
General Teaching Hospital Praha
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Its existence and support must be therefore one of national priorities. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia, e.g. Next-gen Sequencing Technologies and Applications organized in 2013 in Brno.
Publications
Total number of publications: 57
2020
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Human-like telomeres in Zostera marina reveal a mode of transition from the plant to the human telomeric sequences
Journal of Experimental Botany, year: 2020, volume: 71, edition: 19, DOI
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Characterization of Staphylococcus intermedius Group Isolates Associated with Animals from Antarctica and Emended Description of Staphylococcus delphini
Microorganisms, year: 2020, volume: 8, edition: 2, DOI
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4(+)CD25(+)FoxP3(+) regulatory T cells activation
THERANOSTICS, year: 2020, volume: 10, edition: 2, DOI
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MiR-215-5p Reduces Liver Metastasis in an Experimental Model of Colorectal Cancer through Regulation of ECM-Receptor Interactions and Focal Adhesion
Cancers, year: 2020, volume: 12, edition: 12, DOI
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Novel Splicing Variant in the PMM2 Gene in a Patient With PMM2-CDG Syndrome Presenting With Pericardial Effusion: A Case Report
Frontiers in Genetics, year: 2020, volume: 11, edition: October 2020, DOI
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Recurrent gene mutations detected in canine mast cell tumours by next generation sequencing
VETERINARY AND COMPARATIVE ONCOLOGY, year: 2020, volume: 18, edition: 4, DOI
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Spatial structure of permafrost and active layer from the James Ross Island, Antarctica: Geological and Microbiological Insights
Year: 2020, type: Conference abstract
2019
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A novel germline mutation of the SFTPA1 gene in familial interstitial pneumonia
HUMAN GENOME VARIATION, year: 2019, volume: 6, edition: MAR, DOI
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Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein
RNA, year: 2019, volume: 25, edition: 6, DOI
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Analysis of gene expression in CD26+ CML leukemic stem cell population.
Year: 2019, type: Conference abstract