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Project information
Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants

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Project Identification
GP525/08/P464
Project Period
1/2008 - 12/2010
Investor / Pogramme / Project type
Czech Science Foundation
  • Postdoctoral projects
MU Faculty or unit
Faculty of Science
Keywords
humic substances, AhR-mediated toxicity, dioxin-like toxicity, irradiation, environmental pollutants

Humic substances (HS) are naturally occurring compounds ubiquitous in water, that were shown e.g. to interact with xenobiotics. In consequence of this interaction, properties of afected compounds such as bioavailability and toxicity are changed. Another important environmental factor affecting properties of both HS and xenobiotics is solar irradiation. Among highly hazardous xenobiotics belong dioxin-like compounds such as polychlorinated dioxins, furans and biphenyls, and polycyclic aromatic hydrocarbons. Despite the numerous studies both on HS and dioxin-like substances, and potential irradiation impact, there has not been published any information on alteration of dioxin-like toxicity both by HS and irradiation yet. The project will bring priority ecotoxicological information on changed of dioxin-like toxicity under the influence of HS and irradiation. New method of HS isolation from aquatic environment and new fish model cell line RLT2.0 will be introduced to increase the environmental relevance of obtained results. The final output will be also good quality publications, enhancement of scientific work experience of the applicant, and the methodical development of the research centre.

Publications

Total number of publications: 8

2011

2010

2009

2008

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