Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 359
2011
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The role of p53, p21 and microRNAs in the regulation of human embryonic stem cells response to UVC-induced DNA damage
Year: 2011, type: Conference abstract
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TOMENTODIPLACONE B INHIBITS PROLIFERATION OF HUMAN LEUKEMIA CELLS THROUGH INHIBITION OF CDK2 ACTIVITY AND REDUCTION OF CYCLIN E1 ISOFORM LEVELS
Year: 2011, type: Conference abstract
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Towards Modeling and Therapy of Genetic Diseases Using Pluripotent Stem Cells
Translational Stem Cell Research : Issues Beyond the Debate on the Moral Status of the Human Embyo, year: 2011, number of pages: 12 s.
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Využití denaturační vysokotlaké kapalinové chromatografie pro screening změn genu TP53 u pacientů s chronickou lymfocytární leukemií
Year: 2011, type: Conference abstract
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Význam PCR detekce a kvantifikace herpetických virů v bronchoalveolární laváži imunokompromitovaných pacientů.
Klinická mikrobiologie a infekční lékařství, year: 2011, volume: 17, edition: 6
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Whole genome analysis of patients with chronic lymphocytic leukemia.
Year: 2011, type: Conference abstract
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Wnt/PCP pathway regulates B-cell migration in chronic lymphocytic leukemia
Year: 2011, type: Conference abstract
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WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Cell Signal, year: 2011, volume: 23, edition: 3, DOI
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Způsob detekce chromozomální translokace t(11;14)(q13;q32) a oligonukleotidy pro použití při tomto způsobu
Publisher: Úřad průmyslového vlastnictví, state: Czech Republic, patent's number: 302581, year: 2011
2010
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A case of a novel PML/RARA short fusion transcript with truncated transcription variant 2 of the RARA gene
Molecular diagnosis and therapy, year: 2010, volume: 14, edition: 2