Project information
Rozlišení a molekulární analýza aloreaktivních a nádorově-specifických T lymfocytů in vitro

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

1A8709

Project Period

8/2005 - 12/2009

Investor / Pogramme / Project type

Ministry of Health of the CR

Health of People (National Research Programme)

MU Faculty or unit

Faculty of Medicine

prof. MUDr. Jaroslav Michálek, Ph.D.
Mgr. Darina Očadlíková, Ph.D.
prof. MUDr. Jaroslav Štěrba, Ph.D.
MUDr. Kateřina Toušovská, Ph.D.

Keywords

T lymfocyt

Náplní projektu je identifikace, rozlišení a molekulární analýza individuálních klonů T lymfocytů zodpovědných za rozvoj reakce štěpu proti hostiteli a reakce štěpu proti nádoru s cílem potlačení aloreaktivity a potenciace protinádorové reaktivity.

Publications

Total number of publications: 26

2011

Multifunctional immune-modulatory protein HLA-E identified on both tumor cells and background microenvironment cells in classical Hodkgin lymphoma: Clinical implications.

KŘENOVÁ Zdenka KŘEN Leoš FABIAN Pavel ŠTĚRBA Jaroslav ET. AL.

Conference abstract

Year: 2011, type: Conference abstract

2010

Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma

MICHÁLEK Jaroslav OČADLÍKOVÁ Darina MATĚJKOVÁ Eva FOLTÁNKOVÁ Veronika DUDOVÁ Silvie SLABÝ Ondřej HORVÁTH Radek POUR Luděk HÁJEK Roman

Article in Periodical

British Journal of Haematology, year: 2010, volume: 148, edition: 6

2009

4th myeloma and 2nd immunotherapy workshop

HÁJEK Roman MICHÁLEK Jaroslav

Workshop

Year: 2009, type: Workshop
Elimination of graft versus host reactivity and preservation of graft versus leukemia and graft versus myeloma effect using selective depletion of donor alloreactive T cells

MICHÁLEK Jaroslav MATĚJKOVÁ Eva FOLTÁNKOVÁ Veronika BARTOŠ M. DENDIS M. HORVATH R.

Conference abstract

Year: 2009, type: Conference abstract
Characterization of T cell receptor beta repertoire in T cell population associated with graft-versus-host and graft-versus-leukemia effect

FOLTÁNKOVÁ Veronika MATĚJKOVÁ Eva BARTOŠ Milan DENDIS Miloš MAYER Jiří HÁJEK Roman MICHÁLEK Jaroslav

Conference abstract

Year: 2009, type: Conference abstract
In Vitro Activation of Cytotoxic T Lymphocytes By Muc1 Pulsed Dendritic Cells

KRYUKOV Fedor OČADLÍKOVÁ Darina KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MATĚJKOVÁ Eva HÁJEK Roman MICHÁLEK Jaroslav

Article in Periodical

The Open Cancer Immunology Journal, year: 2009, volume: 2, edition: 1
In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells

KRYUKOV Fedor OČADLÍKOVÁ Darina KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana HÁJEK Roman MICHÁLEK Jaroslav

Article in Periodical

Journal of immunotoxicology, year: 2009, volume: 6, edition: 4
In vitro activation of myeloma-specific cytotoxic T cells by hTERT pulsed dendritic cells

KRYUKOV Fedor OČADLÍKOVÁ Darina KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MATĚJKOVÁ Eva HÁJEK Roman MICHÁLEK Jaroslav

Conference abstract

Year: 2009, type: Conference abstract
In vitro activation of myeloma-specific cytotoxic T cells by MUC1 pulsed dendritic cells

KRYUKOV Fedor ZAHRADOVÁ Lenka OČADLÍKOVÁ Darina KOVÁŘOVÁ Lucie MATĚJKOVÁ Eva HÁJEK Roman MICHÁLEK Jaroslav

Conference abstract

Year: 2009, type: Conference abstract
Myeloma - specific T-cell clones can eliminate tumor cells and their long-term correlate with clinical outcomes in patients with multiple myeloma

MICHÁLEK Jaroslav MATĚJKOVÁ Eva FOLTÁNKOVÁ Veronika SLABÝ Ondřej HORVÁTH Radek HÁJEK Roman VITETTA Ellen S.

Conference abstract

Year: 2009, type: Conference abstract