Project information
Synthetic Lethal approach for targeting DNA double strand breaks repair defects

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
MUNI/11/InGA16/2013
Project Period
1/2014 - 12/2014
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

DNA damage response (DDR) network is essential for prevention of accumulation of harmful mutations leading to various diseases and tumourigenesis. DDR functions as a cooperation of parallel alternative pathways, buffering each other. Partial disturbance of DDR network in cancer cells make them critically dependent on a single repairing pathway. Such genetic changes in tumour cells predispose them for the therapy by targeting DDR mechanism. This redundancy can be exploited with synthetic lethality (SL) approach. The goal of this proposal is to validate FEN1-MRE11 SL partnership in cancer cells and chemically target it with novel inhibitors of Mre11.The results of this proposal should provide a novel strategy to treat DNA repair-defective tumours with minimal side-effects for the organism.

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