Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Jiří Fajkus, CSc.
- Other MU Faculty/Unit
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Faculty of Medicine
- prof. MUDr. David Šmajs, Ph.D.
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1207
2008
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Synthesis, structure and thermal decomposition of [Ni(NH3)(6)][VO(O-2)(2)(NH3)](2)
Journal of Thermal Analysis, year: 2008, volume: 91, edition: 1
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Synthesis, X-ray crystal structure and thermal decomposition of two peroxovanadium complexes with coordinated ammonia molecules: [{VO(O-2)2(NH3)}(2){[mu-Cu(NH3)(4)}] and [Zn(NH3)(4)][VO(O-2)(2)(NH3)](2)
Polyhedron, year: 2008, volume: 27, edition: 2
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Telomere repeat binding protein variants show distinct kinetics and energetic nature of DNA-protein interaction
Year: 2008, type: Conference abstract
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The Arabidopsis thaliana response regulator ARR22 is a putative AHP phospho-histidine phosphatase expressed in the chalaza of developing seeds
BMC Plant Biology, year: 2008, volume: 8, edition: 77
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The effects of TGFb proteins on osteoclast differentiation
Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, year: 2008
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The Histidine Kinase AHK5 Integrates Endogenous and Environmental Signals in Arabidopsis Guard Cells
PloS ONE, year: 2008, volume: 3, edition: 6
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The identification of cells with cancer stem cell phenotype in osteosarcomas.
Year: 2008, type: Conference abstract
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The identification of cells with cancer stem cell phenotype in pediatric solid tumors.
XIX. Biologické dny - Biologický výzkum pro lidské zdraví. Program a sborník abstrakt., year: 2008
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The influence of LOX/COX inhibitors on the ATRA induced differentiation in neuroblastoma cell lines.
International Journal of Mol. Medicine 22 (Sup. 1) - the 13th World Congress on Advances in Oncology and the 11th International Symposium on Molecular Medicine., year: 2008
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The poor prognosis associated with gain/amplification of 1q21 in relapsed multiple myeloma patients may be overcome by Velcade based regimen in contrary of thalidomide based regimen
Year: 2008, type: Conference abstract