Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Jiří Fajkus, CSc.
- Other MU Faculty/Unit
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Faculty of Medicine
- prof. MUDr. David Šmajs, Ph.D.
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1207
2008
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Hematologie: přehled maligních hematologických nemocí
Year: 2008, edition: Vyd. 2., number of pages: 404 s.
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Histiocytární choroby
Hematologie: přehled maligních hematologických nemocí, edition: Vyd. 2., year: 2008, number of pages: 20 s.
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Hormone interactions at the root apical meristem
Plant Molecular Biology, year: 2008, volume: 10, edition: 1007
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Characteristics of Panton - Valentine leukocidin positive <I>Staphylococcus aureus</I> strains isolated in the Czech Republic
13th International Symposium on Staphylococci and Staphylococcal Infections, year: 2008
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Characteristics of <I>Staphylococcus aureus</I> strains from 5 outbreaks of pemphigus neonatorum in the Czech Republic and Slovakia
13th International Symposium on Staphylococci and Staphylococcal Infections, year: 2008
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Charakterizace plazmidů klinických kmenů MRSA a možnosti jejich přenosu transdukujícími bakteriofágy
Year: 2008, type: Requested lectures
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Charakterizace PVL-pozitivních kmenů Staphylococcus aureus izolovaných v České republice
Year: 2008, type: Conference abstract
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Choroby způsobené ukládáním patologických proteinů v tkáních
Hematologie: přehled maligních hematologických nemocí, edition: Vyd. 2., year: 2008, number of pages: 20 s.
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Chromosomal phylogeny and karyotype evolution in x=7 crucifer species (Brassicaceae)
Plant Cell, year: 2008, volume: 20, edition: October
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Chronická B-lymfatická leukemie
Hematologie :přehled maligních hematologických nemocí, edition: Vyd. 2., year: 2008, number of pages: 20 s.