Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Jiří Fajkus, CSc.
- Other MU Faculty/Unit
-
Faculty of Medicine
- prof. MUDr. David Šmajs, Ph.D.
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1208
2009
-
Identifikace genů rezistence k padlí travnímu u planého ječmene Hordeum vulgare ssp. spontaneum PI391126
XIII. Pracovní setkání biochemiků a molekulárních biologů, year: 2009
-
Identifikace nestin/CD133 pozitivních buněk v solidních nádorech mesenchymálního původu
XXXIII. Brněnské onkologické dny - edukační sborník, year: 2009
-
Imunitní odpověď po imunizaci myší BALB/c různými kmeny Borrelia afzelii izolovanými z různých zdrojů
Year: 2009, type: Conference abstract
-
In vitro translace a imunoprecipitace: problémy a jejich řešení
Bulletin České společnosti experimentální biologie rostlin a Fyziologické sekce Slovenské botanické společnosti, year: 2009
-
Interaction of quaternary benzo[c]phenanthridine alkaloids with DNA
Analytical Cytometry V Book of Abstracts, year: 2009
-
Interactions of the receiver domain in histidine kinase receptors with the AHP proteins
Year: 2009, type: Conference abstract
-
Introduction of DNA microarray in molecular diagnostics of Wilson disease
Časopis lékařů českých, year: 2009, volume: 148, edition: 3
-
Investigation of relationships between barley stress peptides and beer gushing using SDS-PAGE and MS screening
Journal of Separation Science, year: 2009, volume: 32, edition: 22
-
Kolicin FY - nový bakteriocín rodu Yersinia.
Year: 2009, type: Conference abstract
-
Komparativní analýza genomů Treponema pallidum subspecies pertenue a Treponema pallidum subspecies pallidum.
Year: 2009, type: Conference abstract