Liam Keegan, PhD.

2026

• ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability

  VUKIĆ Dragana DU Qiupei CHERIAN Anna AMORUSO Damiano BROŽINOVÁ Květoslava WACHEUL Ludivine LACOVICH STRAŠIL Valentina ZORBAS Christiane YADAV Leena SEDMÍK Jiří KESKITALO Salla HAJJI Khadija STEJSKAL Stanislav VARJOSALO Markku LAFONTAINE Denis KEEGAN Liam O'CONNELL Mary Anne

  Peer-reviewed scientific article

  NUCLEIC ACIDS RESEARCH, year: 2026, volume: Volume 54, edition: Issue 8, DOI

• Editing-independent effects of Drosophila Adar on heterochromatin silencing

  HAJJI Khadija AMORUSO Damiano NOVÁKOVÁ Barbora SAMBRANI Nagraj YANG Deying KHAN Anzer BYSTRÝ Vojtěch MEDAGLIA MATA Alejandro SILVESTRIS Domenico Alessandro PICARDI Ernesto O'CONNELL Mary Anne KEEGAN Liam

  Peer-reviewed scientific article

  RNA, year: 2026, volume: 32, edition: 6, DOI

• Microgliosis and aberrant interferon response in Adar Mavs brain are rescued by PKR removal

  LACOVICH STRAŠIL Valentina STEJSKAL Stanislav LOCKER KOVAČOVICOVA Kristina POTĚŠIL David PUSTKA Václav VUKIĆ Dragana TEXLOVA Katerina MUSILOVÁ Pavla MELICHEROVÁ Janka SINIGAGLIA Ketty HAVAS Daniel KEEGAN Liam O'CONNELL Mary Anne

  Peer-reviewed scientific article

  BRAIN, year: 2026, volume: 149, edition: 2, DOI

• Reconfigured immunity in Adar heterozygous and Adar Mavs Eif2ak2 (PKR) triple mutant mice

  MUSILOVÁ Pavla QUIN Jaclyn Elizabeth LOJA Tomáš MELICHEROVÁ Janka DU Qiupei CHERIAN Anna VUKIĆ Dragana MODRÝ David TOMANDLOVÁ Marie CERVENA Barbora STRIBRNA Helena ANN-KRISTIN Ostlund Farrants KNIGHT Andrea KEEGAN Liam O'CONNELL Mary Anne

  Peer-reviewed scientific article

  RNA, year: 2026, volume: 32, edition: 8, DOI

2025

• ADAR1: Beyond Just an RNA Editor

  MARÔNEK Martin LACOVICH STRAŠIL Valentina CHERIAN Anna AMORUSO Damiano MUSILOVÁ Pavla DU Qiupei MELICHEROVÁ Janka KEEGAN Liam O'CONNELL Mary Anne

  Peer-reviewed scientific article

  Annual Review of Cell and Developmental Biology, year: 2025, volume: 41, edition: 1, DOI

• Global analysis by LC-MS/MS of N6-methyladenosine and inosine in mRNA reveal complex incidence

  STEJSKAL Stanislav ŠEMBEROVÁ RÁJECKÁ Veronika COVELO MOLARES Helena SINIGAGLIA Ketty BROŽINOVÁ Květoslava KAŠIAROVÁ Linda DOHNÁLKOVÁ Michaela REYES-GUTIERREZ Paul Eduardo CAHOVÁ Hana KEEGAN Liam O'CONNELL Mary Anne VAŇÁČOVÁ Štěpánka

  Peer-reviewed scientific article

  RNA, year: 2025, volume: 31, edition: 4, DOI

• Novel ADAR2 variants in children with seizures, intellectual disability and motor delay have reduced RNA editing.

  DU Qiupei CHERIAN Anna LOUIE Raymond J BARCIA Giulia RUDY Natasha NABBOUT Rima SARDA Eugenie CHARPIE Maelle PATTERSON Wesley G KEEGAN Liam O'CONNELL Mary Anne

  Peer-reviewed scientific article

  RNA, year: 2025, volume: 31, edition: 9, DOI

2024

• Amyloid precursor protein induces reactive astrogliosis

  JAUREGUI Gretsen Velezmoro VUKIĆ Dragana ONYANGO Isaac G ARIAS Carlos NOVOTNY Jan S TEXLOVA Katerina WANG Shanshan KOVACOVICOVA Kristina Locker POLAKOVA Natalie ZELINKOVA Jana CARNA Maria LACOVICH STRAŠIL Valentina HEAD Brian P HAVAS Daniel MISTRIK Martin ZOREC Robert VERKHRATSKY Alexei KEEGAN Liam O'CONNELL Mary Anne RISSMAN Robert STOKIN Gorazd B

  Peer-reviewed scientific article

  Acta Physiologica, year: 2024, volume: 240, edition: 6, DOI

• An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

  SINIGAGLIA Ketty CHERIAN Anna DU Qiupei LACOVICH STRAŠIL Valentina VUKIĆ Dragana MELICHEROVÁ Janka MUSILOVÁ Pavla ZERAD Lisa STEJSKAL Stanislav MALIK Radek PROCHAZKA Jan BONDURAND Nadege SEDLACEK Radislav O'CONNELL Mary Anne KEEGAN Liam

  Peer-reviewed scientific article

  Cell Reports, year: 2024, volume: 43, edition: 8, DOI

• Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction

  VUKIĆ Dragana CHERIAN Anna KESKITALO Salla BONG Yih Tyng MARÔNEK Martin YADAV Leena KEEGAN Liam VARJOSALO Markku O'CONNELL Mary Anne

  Peer-reviewed scientific article

  Nucleic Acids Research, year: 2024, volume: 52, edition: 22, DOI