Mgr. Michaela Hylsová, Ph.D.

2020

• Furopyridines as inhibitors of protein kinases

  PARUCH Kamil HYLSOVÁ Michaela

  Patent

  Publisher: European Patent Office, state: Germany, patent's number: EP2940022, year: 2020

2019

• Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

  NĚMEC Václav HYLSOVÁ Michaela MAIER Lukáš FLEGEL Jana SIEVERS Sonja ZIEGLER Slava SCHRÖDER Martin BERGER Benedict-Tilman CHAIKUAD Apirat VALČÍKOVÁ Barbora ULDRIJAN Stjepan DRÁPELA Stanislav SOUČEK Karel WALDMANN Hebert KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2019, volume: 58, edition: 4, DOI

2018

• Furopyridines as inhibitors of protein kinases

  PARUCH Kamil HYLSOVÁ Michaela NĚMEC Václav

  Patent

  Publisher: , state: United States of America, patent's number: US 9902733 B2, year: 2018

• Furopyridines as inhibitors of protein kinases

  PARUCH Kamil HYLSOVÁ Michaela NĚMEC Václav

  Patent

  Publisher: Japonský patentový úřad (JPO), state: Japan, patent's number: JP 6386585, year: 2018

2017

• Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

  HYLSOVÁ Michaela CARBAIN Benoit, Jean-Pierre FANFRLIK Jindřich MUSILOVÁ Lenka HALDAR Susanta KOPRULUOGLU Cemal AJANI Haresh BRAHMKSHATRIYA Pathik JORDA Radek KRYŠTOF Vladimír HOBZA Pavel ECHALIER Aude PARUCH Kamil LEPŠÍK Martin

  Article in Periodical

  European Journal of Medicinal Chemistry, year: 2017, volume: 126, edition: January, DOI

• Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles

  NEKARDOVÁ Michaela VYMĚTALOVÁ Ladislava KHIRSARIYA Prashant Kumar KOVÁČOVÁ Silvia HYLSOVÁ Michaela JORDA Radek KRYŠTOF Vladimír FANFRLÍK Jindřich HOBZA Pavel PARUCH Kamil

  Article in Periodical

  ChemPhysChem, year: 2017, volume: 18, edition: 7, DOI

2015

• Substituované furo[3,2-b]pyridiny pro použití jako léčiva

  PARUCH Kamil PETRŮJOVÁ Michaela

  Patent

  Publisher: Úřad průmyslového vlastnictví, state: Czech Republic, patent's number: 305472, year: 2015