RNDr. Petr Chlapek, DiS., Ph.D.

2022

• Serotonin limits generation of chromaffin cells during adrenal organ development

  KAMENEVA Polina MELNIKOVA Victoria I. KASTRITI Maria Eleni KURTOVA Anastasia KRYUKOV Emil MURTAZINA Aliia FAURE Louis POVERENNAYA Irina ARTEMOV Artem V. KALININA Tatiana S. KUDRYASHOV Nikita V. BADER Michael ŠKODA Jan CHLAPEK Petr CURYLOVÁ Lucie SOURADA Lukáš NERADIL Jakub TESAROVA Marketa PASQUALETTI Massimo GASPAR Patricia YAKUSHOV Vasily D. SHEFTEL Boris I. ZIKMUND Tomas KAISER Jozef FRIED Kaj ALENINA Natalia VORONEZHSKAYA Elena E. ADAMEYKO Igor

  Article in Periodical

  Nature Communications, year: 2022, volume: 13, edition: 1, DOI

• Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

  KRCHNIAKOVÁ Mária PAUKOVČEKOVÁ Silvia CHLAPEK Petr NERADIL Jakub ŠKODA Jan VESELSKÁ Renata

  Article in Periodical

  Frontiers in Pharmacology, year: 2022, volume: 13, edition: September, DOI

• Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors

  PAUKOVČEKOVÁ Silvia KRCHNIAKOVÁ Mária CHLAPEK Petr NERADIL Jakub ŠKODA Jan VESELSKÁ Renata

  Article in Periodical

  International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 15, DOI

2021

• A selective p53 activator and anticancer agent to improve colorectal cancer therapy

  RAMOS Helena SOARES Maria I.L SILVA Joana RAIMUNDO Liliana CALHEIROS Juliana GOMES Célia REIS Flávio MONTEIRO Filipe A. NUNES Cláudia REIS Salette BOSCO Bartolomeo PIAZZA Silvano DOMINGUES Lucília CHLAPEK Petr VLČEK Petr FABIAN Pavel RAJADO Ana Teresa CARVALHO A.T.P. VESELSKÁ Renata INGA Alberto MELO Teresa M.V.D. Pinho e SARAIVA Lucília

  Article in Periodical

  Cell Reports, year: 2021, volume: 35, edition: 2, DOI

2020

• Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms

  PAUKOVČEKOVÁ Silvia ŠKODA Jan NERADIL Jakub MIKULENKOVÁ Erika CHLAPEK Petr ŠTĚRBA Jaroslav RICHARDSON Desi Raymond VESELSKÁ Renata

  Article in Periodical

  Cancers, year: 2020, volume: 12, edition: 12, DOI

• Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration

  KRCHNIAKOVÁ Mária ŠKODA Jan NERADIL Jakub CHLAPEK Petr VESELSKÁ Renata

  Article in Periodical

  International Journal of Molecular Sciences, year: 2020, volume: 21, edition: 9, DOI

2019

• Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy

  VESELSKÁ Renata JEŽOVÁ Marta KÝR Michal MAZÁNEK Pavel CHLAPEK Petr DOBROTKOVÁ Viera ŠTĚRBA Jaroslav

  Article in Periodical

  Frontiers in Oncology, year: 2019, volume: 9, edition: NOV 15, DOI

• New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

  GOMES Sara RAIMUNDO Liliana Sofia Gomes SOARES Joana LOUREIRO Joana B. LEAO Mariana NOGUEIRA RAMOS ROCHA Helena Isabel MONTEIRO Madalena N. LEMOS Agostinho MOREIRA Joana PINTO Madalena CHLAPEK Petr VESELSKÁ Renata SOUSA Emília SARAIVA Lucília

  Article in Periodical

  Cancer Letters, year: 2019, volume: 446, edition: 4, DOI

• Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers

  DOBROTKOVÁ Viera CHLAPEK Petr JEŽOVÁ Marta ADÁMKOVÁ Kateřina MAZÁNEK Pavel ŠTĚRBA Jaroslav VESELSKÁ Renata

  Article in Periodical

  PLOS ONE, year: 2019, volume: 14, edition: 6, DOI

2018

• Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy

  DOBROTKOVÁ Viera CHLAPEK Petr MAZÁNEK Pavel ŠTĚRBA Jaroslav VESELSKÁ Renata

  Article in Periodical

  BMC Cancer, year: 2018, volume: 18, edition: 1059, DOI