doc. Mgr. Karel Souček, Ph.D.

2025

• Cell adhesion and EMT markers as downstream effectors of CKB signaling in metastatic process

  POKLUDOVÁ Jana LAPČÍK Petr BOUCHAL Pavel SOUČEK Karel KNOPFOVÁ Lucia BENEŠ Petr

  Conference abstract

  Year: 2025, type: Conference abstract

• Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

  BOSÁKOVÁ Michaela POOVAKULATHU ABRAHAM Sara WACHTELL Davis ZIEBA Jennifer T KOT Alexander NITĂ Alexandru CZYREK Aleksandra Anna KOUDELKA Adolf URSACHI Vlad-Constantin FEKETOVÁ Zuzana RICO-LLANOS Gustavo SVOZILOVÁ Kateřina KOCEROVÁ Petra FAFÍLEK Bohumil GREGOR Tomáš KOTAŠKOVÁ Jana DURAN Ivan VAŇHARA Petr DOUBEK Michael MAYER Jiří SOUČEK Karel KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Cell Communication and Signaling, year: 2025, volume: 23, edition: 1, DOI

• Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode

  MARTÍN MOYANO Paula KUBINA Tadeáš PARUCH Štěpán Owen JAROŠKOVÁ Aneta NOVOTNÝ Jan SKOČKOVÁ Veronika OVESNÁ Petra SUCHÁNKOVÁ Tereza PROKOFEVA Polina KUSTER Bernhard ŠMÍDA Michal CHAIKUAD Apirat KRÄMER Andreas KNAPP Stefan SOUČEK Karel PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2025, volume: 64, edition: 1, DOI

• Tropomyosin 2 isoform Tpm2.3 is a tumour suppressor and a good prognostic factor in osteosarcoma

  ROUSOVÁ Andrea POKLUDOVÁ Jana KNOPFOVÁ Lucia NAVRÁTIL Jiří KAHOUNOVÁ Zuzana SOUČEK Karel MORACZEWSKA Joanna BENEŠ Petr

  Conference abstract

  Year: 2025, type: Conference abstract

• Tropomyosin isoform Tpm2.3 inhibits osteosarcoma progression and metastasis

  ROUSOVÁ Andrea POKLUDOVÁ Jana KNOPFOVÁ Lucia NAVRÁTIL Jiří KAHOUNOVÁ Zuzana SOUČEK Karel MORACZEWSKA Joanna BENEŠ Petr

  Conference abstract

  Year: 2025, type: Conference abstract

2024

• Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives

  PROCHÁZKOVÁ Jiřina KAHOUNOVA Zuzana VONDRÁČEK Jan SOUČEK Karel

  Article in Periodical

  TRANSCRIPTION-AUSTIN, year: 2024, DOI

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

  VALČÍKOVÁ Barbora VADOVIČOVÁ Natália SMOLKOVÁ Karolína ZACPALOVÁ Magdaléna KREJČÍ Pavel LEE Shannon RAUCH Jens KOLCH Walter ALEXANDER von Kriegsheim DOROTÍKOVÁ Anna ANDRYSÍK Zdeněk VICHOVA Rachel VACEK Ondřej SOUČEK Karel ULDRIJAN Stjepan

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2024, volume: 121, edition: 44, DOI

• Lipidomic analysis of tetraspanin-deficient extracellular vesicles

  SMOLKO Martin KOVÁČ Ondrej VYHLÍDALOVÁ KOTRBOVÁ Anna BÖHMEOVÁ Nina CELÁ Anežka KOTOUČEK Jan SOUČEK Karel BRYJA Vítězslav HLAVÁČKOVÁ POSPÍCHALOVÁ Vendula

  Conference abstract

  Year: 2024, type: Conference abstract

• Lipidomic profiling of extracellular vesicles from tetraspanin-deficient cell lines

  SMOLKO Martin KOVÁČ Ondrej VYHLÍDALOVÁ KOTRBOVÁ Anna BÖHMEOVÁ Nina CELÁ Anežka KOTOUČEK Jan SOUČEK Karel BRYJA Vítězslav HLAVÁČKOVÁ POSPÍCHALOVÁ Vendula

  Conference abstract

  Year: 2024, type: Conference abstract