doc. Mgr. Karel Souček, Ph.D.

2025

• Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode

  MARTÍN MOYANO Paula KUBINA Tadeáš PARUCH Štěpán Owen JAROŠKOVÁ Aneta NOVOTNÝ Jan SKOČKOVÁ Veronika OVESNÁ Petra SUCHÁNKOVÁ Tereza PROKOFEVA Polina KUSTER Bernhard ŠMÍDA Michal CHAIKUAD Apirat KRÄMER Andreas KNAPP Stefan SOUČEK Karel PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2025, volume: 64, edition: 1, DOI

2024

• Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives

  PROCHÁZKOVÁ Jiřina KAHOUNOVA Zuzana VONDRÁČEK Jan SOUČEK Karel

  Article in Periodical

  TRANSCRIPTION-AUSTIN, year: 2024, DOI

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

  VALČÍKOVÁ Barbora VADOVIČOVÁ Natália SMOLKOVÁ Karolína ZACPALOVÁ Magdaléna KREJČÍ Pavel LEE Shannon RAUCH Jens KOLCH Walter ALEXANDER von Kriegsheim DOROTÍKOVÁ Anna ANDRYSÍK Zdeněk VICHOVA Rachel VACEK Ondřej SOUČEK Karel ULDRIJAN Stjepan

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2024, volume: 121, edition: 44, DOI

• Lipidomic analysis of tetraspanin-deficient extracellular vesicles

  SMOLKO Martin KOVÁČ Ondrej VYHLÍDALOVÁ KOTRBOVÁ Anna BÖHMEOVÁ Nina CELÁ Anežka KOTOUČEK Jan SOUČEK Karel BRYJA Vítězslav HLAVÁČKOVÁ POSPÍCHALOVÁ Vendula

  Conference abstract

  Year: 2024, type: Conference abstract

• Lipidomic profiling of extracellular vesicles from tetraspanin-deficient cell lines

  SMOLKO Martin KOVÁČ Ondrej VYHLÍDALOVÁ KOTRBOVÁ Anna BÖHMEOVÁ Nina CELÁ Anežka KOTOUČEK Jan SOUČEK Karel BRYJA Vítězslav HLAVÁČKOVÁ POSPÍCHALOVÁ Vendula

  Conference abstract

  Year: 2024, type: Conference abstract

• Orthotopic model for the analysis of melanoma circulating tumor cells

  PÍCKOVÁ Markéta KAHOUNOVÁ Zuzana RADASZKIEWICZ Tomasz Witold PROCHÁZKOVÁ Jiřina FEDR Radek NOSKOVÁ Michaela RADASZKIEWICZ Katarzyna Anna OVESNÁ Petra BRYJA Vítězslav SOUČEK Karel

  Article in Periodical

  Scientific Reports, year: 2024, volume: 14, edition: 1, DOI

• Proteomic analysis of tetraspanin-deficient extracellular vesicles

  RAKYTOVÁ Janka SMOLKO Martin VYHLÍDALOVÁ KOTRBOVÁ Anna GÖMÖRYOVÁ Kristína CELÁ Anežka KOTOUČEK Jan PUSTKA Václav ZDRÁHAL Zbyněk SOUČEK Karel BRYJA Vítězslav HLAVÁČKOVÁ POSPÍCHALOVÁ Vendula

  Conference abstract

  Year: 2024, type: Conference abstract

• Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity

  PROCHAZKOVA Jirina FEDR Radek HRADILOVÁ Barbora KVOKAČKOVÁ Barbora SLAVIK Josef KOVAC Ondrej MACHALA Miroslav FABIAN Pavel NAVRATIL Jiri KRACALIKOVA Simona LEVKOVA Monika OVESNÁ Petra BOUCHAL Jan SOUČEK Karel

  Article in Periodical

  JOURNAL OF LIPID RESEARCH, year: 2024, volume: 65, edition: 9, DOI

• The effect of tropomyosin isoform Tpm2.3 overexpression on osteosarcoma growth and metastasis

  ROUSOVÁ Andrea POKLUDOVÁ Jana KNOPFOVÁ Lucia NAVRÁTIL Jiří KAHOUNOVÁ Zuzana SOUČEK Karel MORACZEWSKA Joanna BENEŠ Petr

  Conference abstract

  Year: 2024, type: Conference abstract