doc. MUDr. Markéta Bébarová, Ph.D.

Curriculum vitae

Person Identification

• Assoc. Prof. Markéta Bébarová, MD, PhD, born on 23th September 1976 in Hodonín (Czech Republic)

Workplace

• Department of Physiology
  Faculty of Medicine
  Masaryk University
  Kamenice 5
  625 00 Brno
  Czech Republic

Employment Position

• Associate Professor

Education and Academic Qualifications

• 2014 - Assoc. Prof.: Medical Physiology, Masaryk University, Brno; title: „Analysis of electrical properties of cardiac cells: changes induced by drugs, ethanol and sodium channel mutation (the patch clamp technique)“
• 2005 - PhD: Physiology and Pathological Physiology, Masaryk University, Brno; theses: "Effect of antiarrhythmic drug ajmaline on electrophysiological properties of working cardiomyocyte"; supervisor: Doc. RNDr. Ing. Jiří Šimurda, CSc.
• 2001 - MD: General Medicine, Masaryk University, Brno

Employment

• February 2014 - present: Associate Professor, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)
• September 2006 - January 2014: Lecturer, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)
• April 2005 - August 2006: Postdoctoral Research Fellow, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht (The Netherlands)
• October 2004 - April 2005: Assistant, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)

Pedagogical Activities

• Physiology - practicals, tutorials, lectures

Scientific and Research Activities

• Areas of interest:
  Effect of drugs on ionic currents in ventricular myocytes
  Ionic currents in the course of action potential
  Biophysical characterization of wild-type and mutant channels in hereditary cardiovacular diseases (Brugada syndrome, Long QT syndrome type 1) and myotonia congenita
  
• Main Research Projects:
  Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926CT (p.T309I) as a possible long QT syndrome founder mutation (16-30571A; 2016-2019; as the co-investigator)
  Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents: a link to atrial fibrillation related to alcohol consumption? (NT14301-3/2013; 2013-2015; as the principal investigator)
  Effects of ajmaline on membrane currents in cardiomyocytes (FRVS/492/2003; 2003; as the principal investigator)
  Institutional Projects: MUNI/A/1365/2015 (2016; MU), MUNI/A/1326/2014 (2015; MU), MSM0021622402 (2005-2011; MŠMT), J07/98: 141100004 (2000-2004; MŠMT)
  
• Publication Activity - Summary:
  43 peer-review papers including 28 in journals with IF
  over 70 contributions presented at scientific conferences
  188 sum of times cited according to Web of Science (without self-citations); h-index: 9
  
• Membership in Scientific Societies:
  since 2011: member of the European Working Group on Cardiac Cellular Electrophysiology 2012-2016 and 2020-present – the nucleus member)
  since 2002: member of the Czech Physiological Society

Academical Stays

• April 2005 - August 2006: Postdoctoral Research Fellow, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht (The Netherlands)

Appreciation of Science Community

• 2012-2016 and 2020-present: nucleus member of the European Working Group on Cardiac Cellular Electrophysiology (European Society of Cardiology)
• June 2007 - the second prize at Prix de Pharmacie 2007 (Ambassade de France and Sanofi-Aventis)
• November 2003 - the first prize at the conference of Czech postgradual students MediForum, Brno
• February 2003 - one of the four prizes at 79th Physiological Days (conference of Czech and Slovak Physiological Societies)
• November 2002 - the first prize at the conference of Czech postgradual students MediForum, Brno

Selected Publications

• BÉBAROVÁ, Markéta. Electrophysiological cellular effects of sex hormones. In Marek Malik. Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women. 1st edition. Neuveden: Academic Press, 2020, s. 201-210. ISBN 978-0-12-817728-0. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-817728-0.00017-6. URL info
• SUTANTO, Henry, Matthijs J.M. CLUITMANS, Dobromir DOBREV, Paul G.A. VOLDERS, Markéta BÉBAROVÁ a Jordi HEIJMAN. Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. Journal of Molecular and Cellular Cardiology. Oxford: Elsevier, 2020, roč. 146, September 2020, s. 69-83. ISSN 0022-2828. Dostupné z: https://dx.doi.org/10.1016/j.yjmcc.2020.07.007. URL info
• BÉBAROVÁ, Markéta, Zuzana HOŘÁKOVÁ a Roman KULA. Addictive drugs, arrhythmias, and cardiac inward rectifiers. Europace. Oxford: Oxford University Press, 2017, roč. 19, č. 3, s. 346-355. ISSN 1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/euw071. info
• RADASZKIEWICZ, Katarzyna Anna, Dominika SÝKOROVÁ, Lucia BINÓ, Jana KUDOVÁ, Markéta BÉBAROVÁ, Jiřina PROCHÁZKOVÁ, Hana KOTASOVÁ, Lukáš KUBALA a Jiří PACHERNÍK. The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes. Plos ONE. San Francisco: Public Library of Science, 2017, roč. 12, č. 3, s. nestránkováno, 17 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0173140. URL info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Olga ŠVECOVÁ, Roman KULA, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn-Schmiedeberg's Archives of Pharmacology. New York: Springer, 2017, roč. 390, č. 5, s. 471-481. ISSN 0028-1298. Dostupné z: https://dx.doi.org/10.1007/s00210-017-1341-z. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Zuzana HOŘÁKOVÁ, Jan HOŠEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ethanol at clinically relevant concentrations on atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn-Schmiedeberg's Archives of Pharmacology. New York: Springer, 2016, roč. 389, č. 10, s. 1049-1058. ISSN 0028-1298. Dostupné z: https://dx.doi.org/10.1007/s00210-016-1265-z. info
• HOŘÁKOVÁ, Zuzana, Peter MATEJOVIČ, Michal PÁSEK, Jan HOŠEK, Milena ŠIMURDOVÁ, Jiří ŠIMURDA a Markéta BÉBAROVÁ. Effect of ethanol and acetaldehyde at clinically relevant concentrations on atrial inward rectifier potassium current I-K1: Separate and combined effect. Journal of Physiology and Pharmacology. Krakow: Polish Physiological Society, 2016, roč. 67, č. 3, s. 339-351. ISSN 0867-5910. info
• PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study. Medical & Biological Engineering & Computing. Heidelberg: Springer Heidelberg, 2016, roč. 54, č. 5, s. 753-762. ISSN 0140-0118. Dostupné z: https://dx.doi.org/10.1007/s11517-015-1366-8. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, roč. 64, č. 6, s. 939-943. ISSN 0862-8408. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Dual effect of ethanol on inward rectifier potassium current Ik1 in rat ventricular myocytes. Journal of Physiology and Pharmacology. Kraków: Polish Physiological Society, 2014, roč. 65, č. 4, s. 497-509. ISSN 0867-5910. info
• SPÄTJENS, Roel L.H.M.G., Markéta BÉBAROVÁ, Sandrine R.M. SEYEN, Viola LENTINK, Roselie J. JONGBLOED, Yvonne H.J.M. ARENS, Jordi HEIJMAN a Paul G.A. VOLDERS. Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation. Cardiovascular Research. Netherlands: Elsevier Science B.V., 2014, roč. 104, č. 1, s. 216-225. ISSN 0008-6363. Dostupné z: https://dx.doi.org/10.1093/cvr/cvu191. info
• ANDRŠOVÁ, Irena, Markéta BÉBAROVÁ, Roman A. GEBAUER, Jan JANOUŠEK, Peter KUBUŠ, Tomáš NOVOTNÝ, Michal PROCHÁZKA, Jiří RADVANSKÝ, Kryštof SLABÝ, Viktor TOMEK a Pavel VÍT. EKG a dysrytmie v dětském věku. 3., přeprac. a dopl. vyd. Praha: Grada, 2014, 272 s. ISBN 978-80-247-5006-4. info
• BÉBAROVÁ, Markéta. Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts. International Journal of Cardiology. Amsterdam: Elsevier, 2013, roč. 167, č. 5, s. 1760-1771. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2012.12.019. info
• BÉBAROVÁ, Markéta. Advances in patch clamp technique: towards higher quality and quantity. General physiology and biophysics. GENERAL PHYSIOL AND BIOPHYSICS, 2012, roč. 31, č. 2, s. 131-140. ISSN 0231-5882. Dostupné z: https://dx.doi.org/10.4149/gpb_2012_016. info
• KILIANOVÁ, Anna, Markéta BÉBAROVÁ, Klára BERÁNKOVÁ, Radka OPATŘILOVÁ, Michal PÁSEK a Ladislava BARTOŠOVÁ. Effect of Newly Synthesized Compounds 44Bu and 444 on QRS-Complex Width and Fast Sodium Current: Differences between Isomers. Acta Veterinaria Brno. Brno, 2010, roč. 79, č. 1, s. 41-49. ISSN 0001-7213. Dostupné z: https://dx.doi.org/10.2754/avb201079010041. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dana OHLÍDALOVÁ, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. Acta Physiologica. Oxford: Blackwell Publishing, 2010, roč. 200, č. 4, s. 301-314. ISSN 1748-1708. Dostupné z: https://dx.doi.org/10.1111/j.1748-1716.2010.02162.x. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ a Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. Německo: Springer, 2009, roč. 380, č. 2, s. 125-133. ISSN 0028-1298. info
• BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS, Yvonne ARENS, Luz-Maria RODRIGUEZ, Yoram RUDY a Paul VOLDERS. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation. American Journal of Physiology - Heart and Circulatory Physiology. 2008, roč. 295, č. 1, s. H48-H58, 10 s. ISSN 0363-6135. info
• BARTOŠOVÁ, Ladislava, Filip NOVÁK, Markéta BÉBAROVÁ, Marek FRYDRYCH, Vít BRUNCLÍK, Radka OPATŘILOVÁ, Jana KOLEVSKÁ, Petr MOKRÝ, Peter KOLLÁR, Věra STRNADOVÁ a Pavel SUCHÝ. Antiarrhythmic effect of newly synthesized compound 44Bu on model of aconitine-induced arrhythmia - Compared to lidocaine. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2007, roč. 575, 1-3, s. 127-133. ISSN 0014-2999. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK a Marie NOVÁKOVÁ. Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2006, roč. 550, 1-3, s. 15-23. ISSN 0014-2999. info
• BARTOŠOVÁ, Ladislava, Marek FRYDRYCH, G. VACULOVÁ, K. BERÁNKOVÁ, Markéta BÉBAROVÁ, R. OPATŘILOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ, J. KRČMÁŘ, L. BARTOŠÍKOVÁ, T. FLORIAN a J. NEČAS. Ultrashort Bradycardic Effect of Newly Synthetized Compounds. Acta Veterinaria Brunensis. Brno, 2006, roč. 75, č. 2, s. 183-196. ISSN 0001-7213. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ajmaline on transient outward current Ito in rat ventricular myocytes. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2005, roč. 24, č. 1, s. 27-45. ISSN 0231-5882. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes. General Physiology and Biophysics. 2005, roč. 24, č. 3, s. 311-325. ISSN 0231-5882. info
• BARTOŠOVÁ, L., Marek FRYDRYCH, G. HULÁKOVÁ, K. BERÁNKOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ a Markéta BÉBAROVÁ. Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol. Acta Veterinaria Brunensis. Brno, 2004, roč. 73, č. 2, s. 171-179. ISSN 0001-7213. info
• BAHNÍKOVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Ajmaline-induced block of sodium current in rat ventricular myocytes. Scripta medica. Brno, 2002, roč. 75, č. 4, s. 169-177. ISSN 1211-3395. info
• BAHNÍKOVÁ, Markéta, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effects of antiarrhythmics on potassium current sensitive to ATP: comparison of propafenone and trimecaine. Scripta medica. Brno: Lékařská fakulta Brno, 1999, roč. 72, č. 7, s. 299-306. ISSN 1211-3395. info

2021/01/27