The objective of this action is to enable sustainable operation and uptake of the European Genomic Data Infrastructure (GDI)77 that implements the EU Member States’ initiative 1+ Million Genomes (1+MG). According to statements by Member States’ representatives in 1+MG, establishing a European Digital Infrastructure Consortium (EDIC) to operate and maintain the European GDI is the preferred option for the sustainability of the initiative and data infrastructure. This action will support preparatory work for the creation and for operation of an EDIC, facilitate strategic orientation of the 1+MG initiative and support expert work to enable the uptake of genomics for healthcare and public health purposes, as well as the data aspects of the 1+MG Framework.