Informace o projektu
Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe
(ADDIT-CE)
- Kód projektu
- 101087124
- Období řešení
- 1/2023 - 12/2026
- Investor / Programový rámec / typ projektu
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Evropská unie
- Horizont Evropa
- Rozšiřování účasti a posílení ERA
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Další fakulta/pracoviště MU
- Lékařská fakulta
- Další fakulta/pracoviště MU
- Přírodovědecká fakulta
- WWW stránky projektu
- https://addit-ce.ceitec.cz/
- Spolupracující organizace
-
Fakultní nemocnice U sv. Anny Brno
- Odpovědná osoba Katerina Sheardova
- Odpovědná osoba Mgr. Veronika Štěpánková, Ph.D.
- Odpovědná osoba Barbara Ukropcova
- Odpovědná osoba Norbert Žilka
Ministerstvo zdravotníctva Slovenskej Republiky
MultiplexDX
- Odpovědná osoba Adrián Szobi
- Odpovědná osoba Tomas Szemes
Česká alzheimerovská společnost, o.p.s.
- Odpovědná osoba Martina Mátlová
Dementia represents unmet medical need, more than 55 million of people suffer from this fatal disorder. Currently, there is no effective disease modifying therapy. Early diagnosis can significantly reduce total costs. Currently, there is no conceptual plan which would implement the modern diagnostic approaches into the clinical practise in Czech and Slovak republic. The interaction between universities and private sectors leading to the development of molecular diagnostic tools is fragmented and not properly organised. Limited number of talented students are interested in applied neuroscience research focusing on dementia. The main aim of the project is to create two inter-linked ecosystems, in Moravia and Bratislava region, which will encompass the whole quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences will collaborate with private biotech companies. The societal actors will be represented by organisations such as Slovak Alzheimer´s Society, Czech Alzheimer´s society, Centrum Memory and Czech Brain Aging Study. The regional government will be involved through Ministry of Health Slovak Republic, and South Moravian Innovation Centre. The interconnected ecosystems will unite the research and innovation activities focusing on new diagnostic methods and their applications and further interlink academia and business spheres by creating a pilot programme of industrial PhD positions for talented students. The project will generate a joint cross-border strategy covering basic and applied research activities in the field of Alzheimer Disease diagnostics, transfer new cutting-edge technologies into the clinical practise, and accelerate the development of new diagnostic tools for AD diagnostics. The project will join forces of all actors of the involved ecosystems to revolutionise the diagnostic approaches in both countries.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 31
2026
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Deciphering the Tau/14-3-3 Interaction via Artificial Intelligence and Chemical Cross-Linking
Rok: 2026, druh: Další prezentace na konferencích
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Structural and interaction analysis of monomeric 14-3-3ζ phosphorylated at Ser58 by NMR spectroscopy
International Journal of Biological Macromolecules, rok: 2026, ročník: 375, vydání: September, DOI
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Taurine inhibits apolipoprotein E4 aggregation
BIOMEDICINE & PHARMACOTHERAPY, rok: 2026, ročník: 199, vydání: 119395, DOI
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When Proteins Go MAD—Misfolded, Amplified, Detected: Advances in α‑Synuclein Pathophysiology and RT‑QuIC Detection
MOLECULAR NEUROBIOLOGY, rok: 2026, ročník: 63, vydání: 352, DOI
2025
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14-3-3ζ protein prevents formation of GSK3β-phosphorylated Tau protein fibrils
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, rok: 2025, ročník: 330, vydání: November, DOI
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Computational study of the tau protein aggregation
Rok: 2025, druh: Další prezentace na konferencích
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Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins
International Journal of Biological Macromolecules, rok: 2025, ročník: 305, vydání: 2, DOI
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How does phosphorylation of 14-3-3ζ protein affect its structure and function?
Rok: 2025, druh: Konferenční abstrakty
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Characterisation of Alzheimer's-disease-relevant Tau protein expressed in HEK293 mammalian cells
Rok: 2025, druh: Konferenční abstrakty
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Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14-3-3ζ
The FEBS Journal, rok: 2025, ročník: 292, vydání: 8, DOI