Informace o projektu
EXposome Powered tools for healthy living in urbAN SEttings
(EXPANSE)
- Kód projektu
- 874627
- Období řešení
- 1/2020 - 12/2024
- Investor / Programový rámec / typ projektu
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Evropská unie
- Horizon 2020
- Health, demographic change and wellbeing (Societal Challenges)
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Spolupracující organizace
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Universiteit Utrecht
- Odpovědná osoba Prof. Roel Vermeulen
By 2030 more than 80% of Europe’s population will live and interact with a complex urban environment, consisting of a mixture of social and environmental factors. These factors include: where we live and work, where and what we eat, our social network, and what chemical substances we are exposed to. Individually or collectively these factors, known as the Urban Exposome, have an often modifiable impact on our health and provide important targets to improve population health. By studying the impact of the Urban Exposome on the major contributors to Europe’s burden of disease: Cardio-Metabolic and Pulmonary DisWhere we live, what we eat, how much we exercise and many other factors non-generic drivers of disease have an potentially modifiable impact on our health.
This perspective is known as the Exposome. EXPANSE will address one of the most pertinent questions for urban planners, policy makers, and inhabitants in Europe: “How to maximize one’s health in a modern urban environment?”. We distinguish two compartments of the Exposome: the External Exposome capturing complex combinations of environmental, lifestyle and social factors affecting health, and the Internal Exposome, reflecting biological responses to External Exposome stressors. EXPANSE will study the impact of the Urban Exposome on Cardio-Metabolic and Pulmonary Health and by evaluating the impact of intervening on specific factors in the Urban Exposome on reducing the burden of CMPD. EXPANSE will bring together mega-sized administrative
cohorts, comprising the health data of more than 45 million European citizens, large individual adult and matured birth cohorts (> 2 million European citizens), and urban-lab case studies (5,000 individuals). Our goal is to create a long-term sustainable toolbox and infrastructure that can be used to generate knowledge on the Urban Exposome and the translation of this knowledge into actionable information for citizens, public sector policy makers, and private sector companies.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 11
2024
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Countrywide analysis of heat- and cold-related mortality trends in the Czech Republic: growing inequalities under recent climate warming
International Journal of Epidemiology, rok: 2024, ročník: 53, vydání: 1, DOI
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Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study)
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, rok: 2024, DOI
2023
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Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort
Environment International, rok: 2023, ročník: 181, vydání: November 2023, DOI
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Development of historic monthly land use regression models of SO2, NOx and suspended particulate matter for birth cohort ELSPAC
Atmospheric Environment, rok: 2023, ročník: 301, vydání: May 2023, DOI
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Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort
Environmental Research, rok: 2023, ročník: 222, vydání: April 2023, DOI
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Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)
International Journal of Hygiene and Environmental Health, rok: 2023, ročník: 252, vydání: July 2023, DOI
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The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study
SCIENCE OF THE TOTAL ENVIRONMENT, rok: 2023, ročník: 881, vydání: July 2023, DOI
2022
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City-scale assessment of long-term air quality impacts on the respiratory and cardiovascular health
Frontiers in Public Health, rok: 2022, ročník: 10, vydání: November 2022, DOI
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Genotoxic effects of transboundary pollutants in Pinus mugo in the high mountain habitats
Ecological indicators, rok: 2022, ročník: 140, vydání: July 2022, DOI
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Merging the exposome into an integrated framework for "omics" sciences
iSCIENCE, rok: 2022, ročník: 25, vydání: 3, DOI