Informace o projektu
DNA as a training platform for photodynamic processes in soft materials — LightDyNAmics
(LightDyNAmics)
- Kód projektu
- 765266
- Období řešení
- 4/2018 - 10/2022
- Investor / Programový rámec / typ projektu
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Evropská unie
- Horizon 2020
- MSCA Marie Skłodowska-Curie Actions (Excellent Science)
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
-
Universität Wien
Ludwig-Maximilians-Universität München
Centre National de la Recherche Scientifique
University of Durham
Politecnico di Milano
Consiglio Nazionale Delle Ricerche
- Odpovědná osoba Roberto Improta
LightDyNAmics network merges excellence, completeness and complementarity: it brings together 10 of Europe`s leading academic groups with first-rate scientific records and a consolidated experience in methods development to master photoactivated processes in macromolecular systems such as DNA. Their expertise covers a wealth of time-resolved spectroscopies and quantum mechanical methods, as well as the conforma-tional characterization of bio-macromolecules and their manipulation with advanced synthetic approaches. The extremely high scientific level of the industrial partners, two SME and one large Company, will contribute to the success of the research activity and will make easier technology transfer.
LightDyNAmics will develop new experimental and computational methods for the study of light/soft-matter interaction. LightDyNAmics will train 15 early stage researchers (ESRs) using a novel mix of experimental, computational and modelling skills. LightDyNAmics will elucidate the photoactivated dynamics of DNA with an unprecedented spatial and time resolution and assess many crucial issues for photodamage, paving the way to new drugs and new diagnostic tools. Our success will enable fundamental technological advances in the use of light as a powerful analytical tool to study Nucleic Acids and their interaction with proteins, drugs, or other molecules with very high spatial and time resolution. Companies will exploit these advances in three cutting-edge applications.
Publikace
Počet publikací: 5
2023
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Atomistic Landscape of Opening-Closing Dynamics of DNA Holliday Junction Obtained by Molecular Simulations
Rok: 2023, druh: Konferenční abstrakty
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Atomistic Picture of Opening–Closing Dynamics of DNA Holliday Junction Obtained by Molecular Simulations
Journal of Chemical Information and Modeling, rok: 2023, ročník: 63, vydání: 9, DOI
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Structural and dynamic effects of pseudouridine modifications on noncanonical interactions in RNA
RNA, rok: 2023, ročník: 29, vydání: 6, DOI
2021
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c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry
Nucleic Acids Research, rok: 2021, ročník: 49, vydání: 15, DOI
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Phosphorothioate Substitutions in RNA Structure Studied by Molecular Dynamics Simulations, QM/MM Calculations, and NMR Experiments
Journal of Physical Chemistry B, rok: 2021, ročník: 125, vydání: 3, DOI