Informace o projektu
Elektrostaticky zvlákněná biodegradabilní nanovlákna pokrytá plazmově připravenými aminovými vrstvami pro využití v biomedicíně
- Kód projektu
- LD15150
- Období řešení
- 10/2015 - 5/2017
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- COST CZ (od projektů s počátkem řešení v roce 2011)
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
The aim of this project is to deposit stable amine-rich coatings onto a biodegradable nanofibrous material and to prove its increased bioactivity. This proposal coincides with the COST Action MP1206, namely the topic of the working group 3, “Biomedical applications of electrospun nanofibrous materials”. The proposed research will contribute to the promotion of nanofibers for the biomedical use. The particular objectives of the project are:
- Find electrospinning conditions suitable for the preparation of biodegradable nanofibrous mesh with the fiber thickness ~500-1500 nm and the pore size ~5-15 μm.
- Find the conditions of low pressure plasma polymerization of cyclopropylamine and plasma pre-treatment conditions suitable for uniform coating of nanofibers with amine-rich layers.
- Correlate plasma pre-treatment and deposition conditions with the coating chemical structure, adhesion to polymer nanofibers, aging and stability of amine-layers in water.
- Conclude on an enhancement of cell adhesion and proliferation on the amine-coated nanofibrous material compared to the untreated surfaces.
- Determine the exent of an antigen or antibody attachment to the nanofibrous mesh and evaluate a prospectiveness of the application for a controlled vaccination or ant-viral/anti-microbe treatment.
Publikace
Počet publikací: 5
2018
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Grafting of carboxyl groups using CO2/C2H4/Ar pulsed plasma: Theoretical modeling and XPS derivatization
Applied Surface Science, rok: 2018, ročník: 435, vydání: MAR, DOI
2017
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Carboxyl-anhydride and amine plasma coating of PCL nanofibers to improve their bioactivity
MATERIALS & DESIGN, rok: 2017, ročník: 132, vydání: October, DOI
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Cyclopropylamine plasma polymers for increased cell adhesion and growth
Plasma processes and polymers, rok: 2017, ročník: 14, vydání: 7, DOI
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Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers
Nanocon 2016 - Proceedings, rok: 2017
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Structural and Surface Compatibility Study of Modified Electrospun Poly(epsilon-caprolactone) (PCL) Composites for Skin Tissue Engineering
AAPS PHARMSCITECH, rok: 2017, ročník: 18, vydání: 1, DOI