NMR studie přirozeně neuspořádaných proteinů. Structurní studie bakteriální RNA polymerázy a jejích podjednotek. Studie Microtubule associated protein 2c a jeho vazby na mikrotubuly.
The purpose of this stay is to learn advanced methods for analysis of flexible proteins using experimental SAXS and NMR(chemical shifts, PRE, RDC) data. This includes the ASTEROIDS algorithm and other tools developed by the research group of Martin Blackledge in Grenoble.
Vybrané publikace
BARTOŠÍK, Viktor, Jitka PLUCAROVÁ, Alice LANÍKOVÁ, Zuzana JANÁČKOVÁ, Petr PADRTA, Séverine JANSEN, Vojtěch VAŘEČKA, Tobias GRUBER, Stephan M. FELLER a Lukáš ŽÍDEK. Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways. International Journal of Biological Chemistry. ANSInet, 2024, roč. 300, č. 8. ISSN 1819-155X. Dostupné z: https://dx.doi.org/10.1016/j.jbc.2024.107551. URLinfo